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  Drugs like cannabis and heroin come from plants. Other drugs are man-made in laboratories. How a drug is made and what other substances are added to it can vary from time to time and from place to place. You can’t be 100% sure of what you're getting when you use drugs obtained anywhere else except through a reliable pharmacy. Even in the case of purely 'natural drugs' like magic mushrooms, there are risks (for example, unless you know what you’re doing you may pick mushrooms by mistake that are poisonous).